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DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions.
Sun Y, Li S, Shen K, Ye S, Cao D, Yang J. Sun Y, et al. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14939-45. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26823825 Free PMC article.
Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and RARB gene in patients with different cervical disease grade. The detection of gene promoter methylation was conducted in two hundred fi …
Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and …
Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science.
Wentzensen N, Sherman ME, Schiffman M, Wang SS. Wentzensen N, et al. Gynecol Oncol. 2009 Feb;112(2):293-9. doi: 10.1016/j.ygyno.2008.10.012. Epub 2008 Dec 2. Gynecol Oncol. 2009. PMID: 19054549 Free PMC article. Review.
RESULTS: 51 studies were identified analyzing 68 different genes for methylation in 4376 specimens across all stages of cervical carcinogenesis. 15 genes, DAPK1, RASSF1, CDH1, CDKN2A, MGMT, RARB, APC, FHIT, MLH1, TIMP3, GSTP1, CADM1, CDH13, HIC1, and TERT have been analyze …
RESULTS: 51 studies were identified analyzing 68 different genes for methylation in 4376 specimens across all stages of cervical carcinogene …
Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.
Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M, Murty VV. Narayan G, et al. Mol Cancer. 2003 May 13;2:24. doi: 10.1186/1476-4598-2-24. Mol Cancer. 2003. PMID: 12773202 Free PMC article.
We found a high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes. Correlation of promoter methylation with clinical characteristics and other genetic changes revealed the following: a) overall promoter methylation was higher in more advanced stage of t …
We found a high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes. Correlation of promoter methylation with clini …
Quantitative DNA methylation analysis of candidate genes in cervical cancer.
Siegel EM, Riggs BM, Delmas AL, Koch A, Hakam A, Brown KD. Siegel EM, et al. PLoS One. 2015 Mar 31;10(3):e0122495. doi: 10.1371/journal.pone.0122495. eCollection 2015. PLoS One. 2015. PMID: 25826459 Free PMC article.
Compared to HPV and age, the combination of DNA methylation level of DAPK1, SLIT2, WIF1 and RARB with HPV and age significantly improved the AUC from 0.79 to 0.99 (95% CI: 0.97-1.00, p-value = 0.003). ...Alterations in DNA methylation of specific genes in cervical cancers, …
Compared to HPV and age, the combination of DNA methylation level of DAPK1, SLIT2, WIF1 and RARB with HPV and age significantly impro …
Identification of critical microRNA gene targets in cervical cancer using network properties.
Sharma G, Agarwal SM. Sharma G, et al. Microrna. 2014;3(1):37-44. doi: 10.2174/2211536603666140417214659. Microrna. 2014. PMID: 25069511
Based on the topological properties genes were ranked and observed that the gene targets BIRC5 (survivin), HOXA1 and RARB presenting with high Novoseek score of Genecards were enriched in cervical cancer. BIRC5 is an anti- apoptotic protein while HOXA1 and RARB are …
Based on the topological properties genes were ranked and observed that the gene targets BIRC5 (survivin), HOXA1 and RARB presenting …
Detection of hypermethylated genes in women with and without cervical neoplasia.
Feng Q, Balasubramanian A, Hawes SE, Toure P, Sow PS, Dem A, Dembele B, Critchlow CW, Xi L, Lu H, McIntosh MW, Young AM, Kiviat NB. Feng Q, et al. J Natl Cancer Inst. 2005 Feb 16;97(4):273-82. doi: 10.1093/jnci/dji041. J Natl Cancer Inst. 2005. PMID: 15713962
By using logic regression, we determined that the best panel of hypermethylated genes included DAPK1, RARB, or TWIST1. At least one of the three genes was hypermethylated in 57% of samples with CIN-3/CIS and in 74% of samples with ICC but in only 5% of samples with CIN-1 o …
By using logic regression, we determined that the best panel of hypermethylated genes included DAPK1, RARB, or TWIST1. At least one o …
Novel epigenetic changes in CDKN2A are associated with progression of cervical intraepithelial neoplasia.
Wijetunga NA, Belbin TJ, Burk RD, Whitney K, Abadi M, Greally JM, Einstein MH, Schlecht NF. Wijetunga NA, et al. Gynecol Oncol. 2016 Sep;142(3):566-73. doi: 10.1016/j.ygyno.2016.07.006. Epub 2016 Jul 9. Gynecol Oncol. 2016. PMID: 27401842 Free PMC article.
METHODS: We analyzed DNA methylation in 68 HIV-seropositive and negative women with incident CIN1, CIN2, CIN3 and invasive cervical cancer, assaying 120 CpG dinucleotide sites spanning APC, CDH1, CDH13, CDKN2A, CDKN2B, DAPK1, FHIT, GSTP1, HIC1, MGMT, MLH1, RARB, RASSF1, TE …
METHODS: We analyzed DNA methylation in 68 HIV-seropositive and negative women with incident CIN1, CIN2, CIN3 and invasive cervical cancer, …
Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer.
Sun C, Reimers LL, Burk RD. Sun C, et al. Gynecol Oncol. 2011 Apr;121(1):59-63. doi: 10.1016/j.ygyno.2011.01.013. Gynecol Oncol. 2011. PMID: 21306759 Free PMC article.
METHODS: Exfoliated cervical lavage samples positive for HPV16 from women with and without cytomorphic changes of infection (n=46), CIN2 (n=12), and CIN3+ (n=27) were used to interrogate the methylation patterns of the HPV16 L1 gene and upstream regulatory region (URR), five host …
METHODS: Exfoliated cervical lavage samples positive for HPV16 from women with and without cytomorphic changes of infection (n=46), CIN2 (n= …
Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice.
Gutiérrez J, García-Villa E, Ocadiz-Delgado R, Cortés-Malagón EM, Vázquez J, Roman-Rosales A, Alvarez-Rios E, Celik H, Romano MC, Üren A, Lambert PF, Gariglio P. Gutiérrez J, et al. Mol Cell Biochem. 2015 Oct;408(1-2):261-72. doi: 10.1007/s11010-015-2504-1. Epub 2015 Jul 15. Mol Cell Biochem. 2015. PMID: 26173416
In E7-expressing cells, RARB overexpression is further increased in the presence of the tumor suppressor p53 (TP53) R273C mutant. ...These findings indicate that RARB overexpression is part of the early molecular events induced by the E7 oncoprotein....
In E7-expressing cells, RARB overexpression is further increased in the presence of the tumor suppressor p53 (TP53) R273C mutant. ... …
Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women.
Vasiljević N, Scibior-Bentkowska D, Brentnall AR, Cuzick J, Lorincz AT. Vasiljević N, et al. Gynecol Oncol. 2014 Mar;132(3):709-14. doi: 10.1016/j.ygyno.2014.02.001. Epub 2014 Feb 6. Gynecol Oncol. 2014. PMID: 24508839 Free PMC article.
METHODS: Methylation of 26 genes: APC, CADM1, CCND2, CDH13, CDKN2A, CTNNB1, DAPK1, DPYS, EDNRB, EPB41L3, ESR1, GSTP1, HIN1, JAM3, LMX1, MAL, MDR1, PAX1, PTGS2, RARB, RASSF1, SLIT2, SOX1, SPARC, TERT and TWIST1 was measured by pyrosequencing in cytology specimens from a pil …
METHODS: Methylation of 26 genes: APC, CADM1, CCND2, CDH13, CDKN2A, CTNNB1, DAPK1, DPYS, EDNRB, EPB41L3, ESR1, GSTP1, HIN1, JAM3, LMX1, MAL, …
11 results